The CASP results weren't really a big deal. It was a modest advancement using techniques that were already spreading throughout the community, coupled with a skilled team that understood the score metric very well.

Two state folders can be reversibly folded using empirically determined force fields (two state folders basically go from "any totally unfolded configuration" to "fully folded single structure" in milliseconds); we can just run simulations and let the (quantum-inspired, classically embedded) physics do the folding, or we can use other techniques, like Rosetta (monte carlo plus lots of empirical data from known structures), or evolutionary data-based techniques (like Deepmind and others used).