Very unlikely.

1. The probability of some paradigm changing breakthrough in AI over the next 10 years - the kind that can potentially give you the massive market returns - is extremely low.

2. The breakthroughs that will happen will most likely come from the big companies with massive budgets and talented research teams.

AI startup are fighting a losing battle.

What you said has always been true, in every field.

Microsoft, Google, Amazon, Netflix, Facebook - all of them competed with big companies when they started and none of them relied on any single paradigm changing breakthrough, yet they managed to change paradigms.