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A comment on Microdosing LSD for Alzheimer’s proves safe in early human trial. Parent comment

Re:Microdosing LSD for Alzheimer’s proves safe in early huma... by CuriouslyC on Sunday December 22, 2019 @09:22PM (#21861053)
The beta amyloid theory is pretty tired at this point since the correlation between plaques and Alzheimer's is only moderate.

Imo Alzheimer's is probably more related to the brain falling into dysdunctional, self reinforcing patterns of synaptic connectivity.

Neural plaques might exacerbate this problem by disrupting connectivity, but clearly the brains of many people with plaques learn to route around this damage to retain functionality.

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Re:Microdosing LSD for Alzheimer’s proves safe in early huma... by bransonf on Sunday December 22, 2019 @09:49PM (#21861152)
> self reinforcing patterns of synaptic connectivity

Any sources for this? I’d be very interested to read the literature on this.

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Re:Microdosing LSD for Alzheimer’s proves safe in early huma... by CuriouslyC on Sunday December 22, 2019 @10:04PM (#21861214)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207354/

Just a jumping off point review on the weakness of the amyloid theory.

The connectome dysregulation theory is my own, it hasn't appeared in the scientific literature as of yet due to our inability to perform fine mapping of synaptic connections without microtoming a cadaver brain.

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Re:Microdosing LSD for Alzheimer’s proves safe in early huma... by kortex on Monday December 23, 2019 @09:07AM (#21863644)
That's a cool theory. The brain tries pretty hard to maintain criticality (hard as in, disruptions cause it to return to that setpoint quickly). It's possible that inability to recover or maintain optimal processing criticality can lead to corruption of the connectome.

https://www.sciencedaily.com/releases/2019/10/191007113314.h...

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