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Re:Microdosing LSD for Alzheimer’s proves safe in early huma... by CuriouslyC on Sunday December 22, 2019 @10:04PM (#21861214)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207354/

Just a jumping off point review on the weakness of the amyloid theory.

The connectome dysregulation theory is my own, it hasn't appeared in the scientific literature as of yet due to our inability to perform fine mapping of synaptic connections without microtoming a cadaver brain.

Re:Microdosing LSD for Alzheimer’s proves safe in early huma... by kortex on Monday December 23, 2019 @09:07AM (#21863644)
That's a cool theory. The brain tries pretty hard to maintain criticality (hard as in, disruptions cause it to return to that setpoint quickly). It's possible that inability to recover or maintain optimal processing criticality can lead to corruption of the connectome.

https://www.sciencedaily.com/releases/2019/10/191007113314.h...