While the liver toxicity alone would seem to argue against indiscriminate acetaminophen (google tells me that is the same as "paracetamol" but that is a new name to me) use, I would expect common sense to argue against indiscriminate use of anything that is not simply food. I'd look to evidence like you provide to advise me as to how, exactly, I should discriminate. But indiscriminate use of most things seems inadvisable.