I thought it was still just a neat tool to automate clicks, but then I played Path of Exile for a bit and found POE Trade Macro. It stunned me what it could do. Hover over an item, hit a key, it performs an API call to lookup a price and display it in a popup window over the game.

At work we evaluated other solutions like Blue Prism for our internal apps but Auto Hot Key never got a mention. I wonder why.