You certainly can - I have. We moved to downtown Seattle and sold both of our cars. Almost everything is available within a few blocks of walking, I bike commute to the office and can take bus/light rail to most places we need to go. About once a month we rent a car for a day to do further out errands - there are many options for this downtown - ShareNow, Zipcar, Avis etc. It typically costs < $200/mo including insurance etc.