Re:Features of a successful therapeutic fast of 382 days' du...
by jodrellblank on Monday December 02, 2019 @03:09PM
(#21686318)
> the weight loss is principally from calories in, calories out
Is it? Study [1] claims "Mice fed an FS [fat and sugar] diet ad libitum (FSA) consumed the same amount of calories as mice fed within a 9 hr window of the dark phase (FST) [fat and sugar, time restricted] (Figure S2A, i), yet the FST [time restricted] mice gained less body weight"
and then
"to investigate the therapeutic potential of TRF [Time Restricted Feeding], we tested whether TRF could reverse or arrest body weight gain [..] Within a few days the mice were habituated to the new feeding paradigm and continued to consume equivalent calories (Figure S2A, iv). The 13:12 FAT mice showed a modest drop in body weight"
Is it? Study [1] claims "Mice fed an FS [fat and sugar] diet ad libitum (FSA) consumed the same amount of calories as mice fed within a 9 hr window of the dark phase (FST) [fat and sugar, time restricted] (Figure S2A, i), yet the FST [time restricted] mice gained less body weight"
and then "to investigate the therapeutic potential of TRF [Time Restricted Feeding], we tested whether TRF could reverse or arrest body weight gain [..] Within a few days the mice were habituated to the new feeding paradigm and continued to consume equivalent calories (Figure S2A, iv). The 13:12 FAT mice showed a modest drop in body weight"
[1] https://www.cell.com/cell-metabolism/fulltext/S1550-4131(14)...
From related work of https://www.salk.edu/scientist/satchidananda-panda/
I think "it has to be calories in/calories out because it's just common sense" is not nuanced enough for biological systems.