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Re:Psilocybin for major depression granted Breakthrough Ther... by lame-robot-hoax on Tuesday November 26, 2019 @02:33PM (#21641775)
Does it cause any of the anxiety that marijuana can when taken at a small dose? I mean the LSD.

Sometimes if I get too high I get a decent amount of anxiety. Always wanted to try LSD or Shrooms but worried something like that may happen. Generally it comes from me feeling a strange sensation in my body which leads to a slight bit of panic. Or if I get really high I just don’t feel there entirely.

Always thought about taking LSD or Shrooms with some CBD incase I get a bit of anxiety.

Re:Psilocybin for major depression granted Breakthrough Ther... by AnthonBerg on Tuesday November 26, 2019 @04:55PM (#21643147)
I think you’ll be fine.

Anecdotal:

I get very anxious from marijuana. Somewhat manic even. I hate the feeling. I’m generally not a stranger to anxiety in life.

I don’t get anxious from LSD. I _have_ felt anxiety on it that I had been repressing, felt it kind of wash over, but it was ... useful. Not difficult. I knew what it was. I wasn’t lost in it. It wasn’t like being swallowed by the uncomfortable anxiety from marijuana that kind of takes over or drives.

And, well, I think a low LSD dose actually helped me resolve a thread of anxiety I had had since I was a child. An permanent and obsessive safety-seeking walk down an endless tree of decisions and judgement. Kind of a background thread. I kind of ... found it again? Had forgotten it was there? And could revisit it and ... know to stop. “Just stop judging”, i.e. judging the situation. And it felt like I could. It still feels like something was let go of. But idk!; Anecdotal!

There are studies that show that when starting with low doses, then very few people get anxious. Other studies show that when people _do_ get anxious, there are still lasting benefits to well being. As I understand it. There’s a decent seeming summary of this on http://tripsafe.org

Re:Psilocybin for major depression granted Breakthrough Ther... by fjabre on Wednesday November 27, 2019 @11:19AM (#21649147)
There is no comparison between paranoia from weed and a bad trip from mushrooms/lsd.

One can leave you permanently mentally scarred and the other will make you paranoid for a few hours.

I have stoner friends and lsd/mushroom friends. Some of the latter are still dealing with issues today from a single bad experience from a trip they had years ago. I cannot say the same of my stoner friends.

Re:Psilocybin for major depression granted Breakthrough Ther... by heavenlyblue on Wednesday November 27, 2019 @04:11PM (#21652180)
I never had a _really_ bad trip, but I some some things which felt quite evil to me up to the point of pure existential crisis which stayed for some time.
Re:Psilocybin for major depression granted Breakthrough Ther... by lame-robot-hoax on Tuesday November 26, 2019 @07:16PM (#21644108)
Have you done shrooms? Wondering how shrooms work on someone who can get anxiety from weed.
Re:Psilocybin for major depression granted Breakthrough Ther... by StavrosK on Wednesday November 27, 2019 @12:04PM (#21649624)
I also get (mild) anxiety from weed but LSD gives me a nice, relaxed, "everything is great" feeling. Shrooms are very similar, though I get more introspective and depressed unless I'm somewhere nice. I don't like doing LSD/shrooms in my flat or in crowded places, because they bring me down. I'll need to try on a beach or in a forest next time.
Re:Psilocybin for major depression granted Breakthrough Ther... by 19793378 on Tuesday November 26, 2019 @09:59PM (#21644893)
Not the poster, but I had to stop smoking weed because of anxiety and paranoia. I have also taken magic mushrooms in a variety of doses, up to 7g dried, and have not experienced any anxiety or paranoia like I did with weed. I had one magic mushroom experience that started out as a really bad trip, but I was able to manage the anxiety and ride it out until halfway through, when it became a wonderful, uplifting, euphoric experience. Contrast that to that one time I did a dab and had a panic attack and couldn't do anything about it.
Re:Psilocybin for major depression granted Breakthrough Ther... by fjabre on Wednesday November 27, 2019 @11:12AM (#21649086)
I have to disagree. While weed certainly can and does induce anxiety on occasion it is no where near as intense as magic mushroom trips. It’s not on the same level.

A mushroom trip can leave you feeling refreshed regardless but if you have a bad trip it may expose you to your deepest and darkest fears and become a terrifying nightmarish experience that weed couldnt induce if you tried.

The horror of a bad a trip didn’t necessarily teach me anything other than to respect mushrooms much more than weed.

I have had friends say the same. There is no comparison of the paranoia from weed vs the absolute horror of a bad trip.

I feel that people who say there is havent really done a lot of either to know the difference.

Re:Psilocybin for major depression granted Breakthrough Ther... by AnthonBerg on Wednesday November 27, 2019 @12:39PM (#21650023)
It's very dose dependent.

"At a dosage of 1.6 grams in a therapeutic clinical environment, we might expect 0% of people to experience some extreme fear, for an average of around 1 minute of strong anxiety, and we might expect around ~45% to report a persisting positive increase in mood from this dosage assuming they had first tried 0.8 grams, and then 1.6 grams5"

Via https://tripsafe.org/how-to-take-shrooms/#start-small

Based on studies: https://www.ncbi.nlm.nih.gov/pubmed/27578767 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308357/table/T... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308357/

Re:Psilocybin for major depression granted Breakthrough Ther... by 19793378 on Wednesday November 27, 2019 @02:37PM (#21651205)
> I feel that people who say there is havent really done a lot of either to know the difference.

I don't know why you are dismissing my experience like that, or why you think that I do not have a lot of experience. Have you ever had a panic attack? Anxiety and paranoia are something I would get consistently from weed. I never felt the same anxiety, and never felt paranoia, on mushrooms. I never had a panic attack from mushrooms. Almost every psychedelic trip I take (between 50-60 so far) has a range of negative aspects, but I am able to better control myself, something that is not the case with marijuana. I have experienced terror on both mushrooms and LSD, and I was able to keep it together and turn it around every time. FWIW, I also prefer to do relatively large doses (3-5 grams mushrooms, 2-7 hits of LSD).

Re:Psilocybin for major depression granted Breakthrough Ther... by chachachoney on Wednesday November 27, 2019 @01:32PM (#21650558)
>> The horror of a bad a trip didn’t necessarily teach me anything other than to respect mushrooms much more than weed.

Give it time. It can take a decade of reflection to untangle/parse.

Re:Psilocybin for major depression granted Breakthrough Ther... by AnthonBerg on Wednesday November 27, 2019 @05:07AM (#21646638)
I have, and they don't have any similar anxiety-inducing effects on me. On the contrary mushrooms reduce anxiety for me.

A friend did have a very anxious trip - it's possible. However it was topical for him. An introspection into deep issues of security and control, and probably a too high dose for that occasion in his life, with not much experience. But he's fine after!

The psilocybin family's effect is imo a bit more "fantastically bewildering" than LSD. In a sense like old fairytales are sometimes curiously and bewildering to a child. (Comfortably bewildering!) It's hard to put into words. It's a place of beauty. It can be scary if you're an anxious type (like I am myself) and go in a bit fast. (Haven't had an anxious experience myself though.) BUT it doesn't have to be scary or uncomfortable even if bewildering - and usually isn't except in exceptional cases - and doesn't occur with low starting doses afaik, there are still lasting benefits even if you get anxious (iow it is processing), it passes, and the interesting thing is that you're somehow always fine if you let go. A kind and insightful tripsitter is all the insurance I would need I think.

It's really interesting and really hard to explain. Maybe check out the studies and study protocols. Plenty of stuff on http://maps.org – As an example, I believe it has been shown that psilocybin mushrooms strongly reduce anxiety in terminal cancer patients. In a lasting way. I cannot imagine a more trapped and anxious state than terminal cancer. So even id there is anxiety while under the influence, it seems to mean something.

Re:Psilocybin for major depression granted Breakthrough Ther... by warent on Tuesday November 26, 2019 @02:51PM (#21641984)
Marijuana can cause feelings of anxiety because it increases your heart rate and the sensitivity to the feeling of your heat beating, which many people's brains interpret as anxiety.

LSD doesn't have this physiological effect though. It's more accurate to say that LSD will amplify whatever you're already feeling or thinking. If you take acid and feel anxious, it can spiral out of control and feel much more intense. On the flip side, if you're feeling peaceful then it will be a calm, happy journey with no feelings of anxiety whatsoever.

Re:Psilocybin for major depression granted Breakthrough Ther... by throwaway837373 on Tuesday November 26, 2019 @03:48PM (#21642518)
LSD does cause anxiety for many, often at the beginning of the trip. I know when it's kicked in because I get a big rush of anxiety that slowly fades over time. So I wouldn't recommend it to people with an uncontrolled anxiety disorder. (If you can control your anxiety, it can be great and quite therapeutic.)
Re:Psilocybin for major depression granted Breakthrough Ther... by devin on Tuesday November 26, 2019 @11:20PM (#21645213)
A friend of mine kept an escape hatch dose of Valium in order to stop the action of things became too intense. I don’t believe the safety net was ever employed, and perhaps simply having the option helped keep some of those feelings at bay.
Re:Psilocybin for major depression granted Breakthrough Ther... by ObscureScience on Tuesday November 26, 2019 @04:11PM (#21642733)
While I don't think I would confuse the sensation with anxiety, it kind of breeds anxiety. I always feel my heart beat, both from the chest, blood vessels and by small "muscle spasms" throughout my body, is there any substance, preferably legal, that can subdue this to some degree?

I'm not having high pressure or high resting pulse and it's so severe that, while not externally visible, causes for example a squeaky bed to squeak in rhythm with my heart beat.

I've had a prescription for Atomoxetin and it had some "body calming" effect but in some sense amplified the aforementioned effect.

Re:Psilocybin for major depression granted Breakthrough Ther... by warent on Tuesday November 26, 2019 @05:11PM (#21643267)
Have you tried meditation? It sounds like something neutral is happening to you and you interpret it as being bad. If you meditate regularly it will change how you relate to it and many other things in positive transformative ways.
Re:Psilocybin for major depression granted Breakthrough Ther... by lame-robot-hoax on Tuesday November 26, 2019 @04:47PM (#21643082)
Marijuana that is like 1:1 CBD:THC or similar seems to help a lot for me. Keeps me from getting freaked out over sensations from my body.
Re:Psilocybin for major depression granted Breakthrough Ther... by pshc on Tuesday November 26, 2019 @04:42PM (#21643048)
I get similar effects, but a simple aspirin seems to subdue them :)
Re:Psilocybin for major depression granted Breakthrough Ther... by devin on Tuesday November 26, 2019 @11:23PM (#21645230)
If someone winds up in the ER for a bad trip, a benzodiazepine is often used. That’s not legal to obtain without a prescription, but well, neither are mushrooms.
Re:Psilocybin for major depression granted Breakthrough Ther... by lame-robot-hoax on Tuesday November 26, 2019 @04:49PM (#21643098)
Yeah generally what happens is if I get some tightness in my chest, or a muscle cramp in my back, or pressure from like a bed or a couch pushing against me, if I smoke too much I have a tendency to interpret that as something wrong with me, not that I just have a cramp cause I’m sitting funny and a muscle got tight.

Do shrooms not have this physiological effect as well? Or just LSD that lacks it?

Re:Psilocybin for major depression granted Breakthrough Ther... by noodle_face_ on Wednesday November 27, 2019 @02:46PM (#21651300)
I have always gotten anywhere between no and way-to-much anxiety when using pot, just depends on quantity, setting, etc. I prefer doing it alone, in small amounts. If I'm going to get stoned it's almost definitely alone.

Psychedelics are the same, for me, times like ten. Fortunately I handle it relatively well, and I just let it ride as "part of the experience" when I trip. Usually the uncomfortable parts go away after the peak, and then it's just awesome for hours. The peak is amazing in its own ways too, but there is (for me) no doubt a have anxiety/body buzz that is just uncomfortable as all get-out.

Re:Psilocybin for major depression granted Breakthrough Ther... by sharadov on Tuesday November 26, 2019 @02:54PM (#21642012)
Depends largely on set and setting. Set - your mental state going into the trip and your personality type. Setting - the surroundings and people around you. You want to have someone to take care of you in case you have a bad trip.