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Re:Psilocybin for major depression granted Breakthrough Ther... by gbrown on Tuesday November 26, 2019 @10:21AM (#21639000)
You don't - you compare it to "standard of care" (antidepressants, CBT, etc.).

If we can compare an inferior treatment to placebo, and we can compare a breakthrough treatment to this established standard, we can evaluate the new treatment.

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