Psilocybin for major depression granted Breakthrough Therapy by FDA

Re:Psilocybin for major depression granted Breakthrough Ther... by jaypeg25 on Tuesday November 26, 2019 @10:19AM (#21638971)

How do you even control for a placebo in a trial like this? I gotta imagine you're either going to know you're on mushrooms or you're not.

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Re:Psilocybin for major depression granted Breakthrough Ther... by gbrown on Tuesday November 26, 2019 @10:21AM (#21639000)

You don't - you compare it to "standard of care" (antidepressants, CBT, etc.).

If we can compare an inferior treatment to placebo, and we can compare a breakthrough treatment to this established standard, we can evaluate the new treatment.

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Re:Psilocybin for major depression granted Breakthrough Ther... by bantheads on Tuesday November 26, 2019 @10:22AM (#21639008)

In the Good Friday Experiment they used niacin for the control group.

https://en.m.wikipedia.org/wiki/Marsh_Chapel_Experiment

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Re:Psilocybin for major depression granted Breakthrough Ther... by Quarrelsome on Tuesday November 26, 2019 @10:21AM (#21638994)

you'd be surprised, people can be super suggestable and think they're high when they're not, especially when they don't have any former experience of the substance.

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Re:Psilocybin for major depression granted Breakthrough Ther... by AnthonBerg on Tuesday November 26, 2019 @10:42AM (#21639217)

The published papers are probably excellent reading material :)

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Re:Psilocybin for major depression granted Breakthrough Ther... by kpennell on Wednesday November 27, 2019 @03:59AM (#21646346)

Read the studies. They definitely use placebos.

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