Desktop and Android users can do this, but iPhone users are still pretty much limited to DNS-based blockers.

I mean, they can install Firefox. (With uBlock)

Firefox on iOS doesn't supports (Firefox) extensions. However Safari does supports content blockers (such as 1Blocker).

It is for this reason that I still cannot use an iPhone as my main device. In spite of the many advantages of iOS devices (camera quality, resale value), it is still primarily a mobile browsing device for me. So the fact that I can't replicate my desktop browsing setup on it, extensions and all, means that I'll be sticking w/ Android and hopefully move towards a Google Play Services-free implementation.

uBlock and uMatrix are a perfect addition to a setup with a dns based filtering system, though by themselves alone do not provide a solution for all use cases. Think smarttv's, consoles, IOS devices, apps, etc. Basically anything that is not android firefox browser or a desktop browser.

Additionally having DNS filtering in place will also prevent information leakage in case something goes wrong with one of your browser plugins.