>Not hiring an Aspie because, say, we need a person who is comfortable with a lot of noise and distractions, is a skill-based decision

No, that's discrimination. Autism is a disability and companies are required to make reasonable accommodations. A hipster startup wouldn't get away with being wheelchair-inaccessible because that would be discriminating against the disabled. Unless you're running a restaurant or factory or operation like that you have no reasonable excuse to discriminate against the disabled.