I think you can get away with a little of that, but you've gotta read the room a bit and have answers for some of it, and without prepping some fiction-loosely-based-in-reality ahead of time, I definitely do not. If everything's great but I no-answer three of those formula "soft" questions that probably looks bad. One, I'm maybe OK. I'm honest about other stuff but you pull out one of those "questions to ask in an interview" questions, you're probably getting a tall tale.

[EDIT] actually I'm fine on "tell me about when you fucked up". I've got a good real answer for that one.

I wouldn't make something up, but you can usually hammer a story into a mould when the need arises. I've never worked with someone I'd call a douchebag, but I've certainly worked with people who have frustrated me by actions like not responding to e-mails, forgetting requests to do things that were their job, and suchlike.

Given this loose criteria, if you tell someone you've never fucked up, and you've never worked with a douchebag, and you've never disagreed with someone at work, they might think you don't have experience working in a medium-sized-or-larger company; or you had managers that insulated you extremely well; or you don't have much self-awareness.