Not easy at all if you don't have any connection. Applying by simply sending a CV won't work at all. It's a different story once you're in then finding a job is pretty easy. I have several friends that have tried and the ones who made it moved first to the Switzerland subsidiary of the company they were already working for. Other had relatives in Switzerland and didn't had any reply to their applications when staying in their birth country. After moving to their relatives in Switzerland they found a job within one month.

AS an American I am sure its almost impossible. On a positive note I do speak German already.

It is a lot easier than the other way around ;)

We managed to hire Americans (and Russians, Chinese, Indians, ...) all right at my previous job. Not every employer is willing or able though, so it definitely limits your options.