If it's entirely CPU bound, you can use multiprocessing to negate most of the GIL issues, and transparently send inputs/outputs between the parent and child processes. If it's I/O bound, then AsyncIO is a great way to express asynchronous workflows. If it's a combination of both I/O and CPU bound workloads, there are ways to mix multiprocessing and AsyncIO to better saturate your cores without losing the simplicity or readability of Python: https://github.com/jreese/aiomultiprocess