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Re:Inbreeding in a European ancestry sample from the contemp... by uj8efdkjfdshf on Sunday October 06, 2019 @03:40PM (#21174514)
Paper claims an conservatively estimated prevalence of 1/3652 for extreme inbreeding which equates to about 18k people, assuming a UK population size of 66 million.

Not great, but nothing world-ending.

Re:Inbreeding in a European ancestry sample from the contemp... by Retric on Sunday October 06, 2019 @06:25PM (#21175599)
It’s also not always about intentional inbreeding.

Many people don’t know who their biological parents are. While not a significant issue with adoption, if a guy has multiple kids who don’t know their siblings in the same area. Then they are likely geographically close and of similar ages...

Re:Inbreeding in a European ancestry sample from the contemp... by dmckeon on Monday October 07, 2019 @12:46AM (#21177583)
Re:Inbreeding in a European ancestry sample from the contemp... by iguy on Sunday October 06, 2019 @03:46PM (#21174573)
And defines this to mean double-first-cousins and closer (perhaps this is standard). Also, as far as I could skim, this is the prevalence today, rather than an estimate of long-run prevalence.

They must surely have data on simple first cousins, but it didn't jump out at me.

Re:Inbreeding in a European ancestry sample from the contemp... by blueblimp on Sunday October 06, 2019 @06:35PM (#21175677)
For traits, the effect on non-double first cousins can be linearly approximated, which (as far as I know) is a good approximation for inbreeding depression.

For example, taking Fluid Intelligence Score (basically how smart you are), in Table 3, its extrapolated effect size is -3.43, so:

First cousin (relationship coefficient 0.125, inbreeding coefficient 0.0625) would give -0.214 to FIS. To put that in context, for medication, that would be considered a small effect size. So inbreeding at that level is a bit like taking a stupid pill.

Re:Inbreeding in a European ancestry sample from the contemp... by wyattpeak on Sunday October 06, 2019 @06:36PM (#21175685)
Simple first cousins have a coefficient of relationship of 0.125, which is below the threshold considered in the paper.

Received wisdom is that a coefficient below 0.25 doesn't cause serious deleterious effect. I have no idea if that's well supported, but I imagine it's relevant to why it wasn't studied.

Re:Inbreeding in a European ancestry sample from the contemp... by azernik on Monday October 07, 2019 @01:32AM (#21177828)
The motivating force for this definition is uncles/aunts and closer; it just so happens that double-first-cousins have the same genetic relatedness as double first cousins.