First, always minimize runtime dependencies. I personally prefer compiled things for this very reason.

Second, if you’re going to include a third party dependency, how are you auditing it? There’s an unexplored area around security here too. The Node.js ecosystem has had a series of incidents where popular packages have had cryptocurrency miners injected into otherwise helpful packages. If you’re depending on third party runtime dependencies: how are you auditing changes and contributions, how are you scanning for vulnerabilities, how are you patching those vulnerabilities if you don’t have an internal fork upon which you build?

Third, RubyGems is a volunteer-run organization. I believe other software ecosystems are similar. From my understanding of the situation, a RubyGems outage would have had similar effect.