This is actually the one use case where I'm happiest with the Mac + touchbar. OSX lets you screenshot a portion of the screen, a particular window, or the entire screen, and save it to clipboard or desktop, and the keyboard combinations to choose between these are pretty hard to remember.

But the touchbar lets you touch a single button, off-screen, and then clearly choose between these options: https://support.apple.com/en-au/HT201361