I just know how a high works on me, and I'd never drive in that condition. It would be really bizarre if a drug that effects behavior/motorics would make no difference on driving. A cursory search shows the issue has been studied for a while too:

https://www.nap.edu/read/18942/chapter/9#114

Certainly there are people who would say it has no effect on them. Met people who thought a few beers makes them better drivers, too.