The unvoiced assumption here is that the universe is fundamentally knowable through rational materialism.

Among the many things we've learned from science is that there are real phenomena that we cannot perceive. We use microscopes, telescopes, x-ray machines and other sensors of all kinds which create simulacra of the real phenomena which we can perceive.

Extend the analogy to our brains -- consider that there are literally thoughts we cannot think. Our brains tells us there are no thoughts we can't think, but our brains may be liars. Is there a way for our brains to grasp the literally incomprehensible?

It’s not hard philosophy but I recommend Letters to a Young Poet by Rainer Maria Rilke

“The only serious question in life is whether to kill yourself or not.” - Camus

Not everyone comes to this conclusion, one line of reasoning is: because there shouldn’t be a meaningless universe in the first place, it must actually have meaning.

The belief that the universe must have a purpose is a trap. It leads you down a particular line of reasoning that ends with you believing in a creator god (or gods), or that the universe itself is divine. You would likely also reason that you have a purpose in the universe that dictates your actions (adherence to religious dogma or doctrine). All of this is baseless and rationalized without objective evidence. Your only certain "purpose" in life is that which you, yourself make.

Yes, and everyone is free to make their purpose and choose that the universe does have meaning...

What is the purpose of this meaning for me, for my life right now? If not, than I shall not care about it. The universe can go f* itself.