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Re:Ebola Is Now Curable by pvaldes on Monday August 12, 2019 @07:37PM (#20681307)
> I want to know how long it will take for Ebola to evolve a resistance to this therapy.

Maybe never. A lot of time in any case, probably. Ebola is a plant's virus adapted to trees. Evolved to use bats (and probably arboreal snakes also) but can't survive for a long time in primates, and can't survive in soil at long term. We are a dead end for it. Would need infected humans munching some inedible leaves of a tropical tree or visiting hollow trunks where bats live.

News cases of Ebola in the future will be from a new strain, but this does not imply evolution or resistance. Is just that the number of ebola specimens in contact with humans is limited.

Re:Ebola Is Now Curable by Medicalidiot on Monday August 12, 2019 @08:23PM (#20681583)
In practical terms, there will be a resistance that develops eventually. Even though the reservoir is hypothesized to be bats, that doesn't have much significance because of its ability spread from person to person without a vector.

What is notable about Ebola is that its virulence keeps dropping while its ability to spread has significantly increased. The larger issue is that Ebola is in areas that don't have the resources to handle any serious outbreak. It's becoming more likely that Ebola is going to be self sustaining soon.

I'm kind of amazed that a comment expressing interest in when this therapy will be obsolete, see that 96% of bacteria are resistant to Penicillin G now, gets a negative response. Drugs are only effective when the pathogen is still sensitive to them.

Re:Ebola Is Now Curable by Dylan16807 on Tuesday August 13, 2019 @02:21AM (#20683261)
For a resistance to develop, ebola that has been exposed to the treatment inside a hospital has to escape back into the wild. There are significant barriers in the way of that.

If everyone on penicillin was kept in an isolation chamber, the effectiveness over time would be different.

Re:Ebola Is Now Curable by Medicalidiot on Tuesday August 13, 2019 @08:51AM (#20685283)
As someone who works in a hospital, we can bleach every single patient room, wear all the PPE we want, but pathogens will always spread; the only question is when, not if. Even in an isolation chamber a resistance to penicillin would develop independently of each other as penicillin resistance is usually predicated on a mutation in the penicillin binding protein.
Re:Ebola Is Now Curable by Dylan16807 on Tuesday August 13, 2019 @01:14PM (#20687895)
Nothing's perfect, but ebola levels of paranoia drastically slow down any chance of spread.

While partial resistance can be encouraged in a single person, that doesn't matter if it dies inside them. And if a resistance mutation happens in the wild, away from drugs, there's no reason to expect it to spread at all.

Re:Ebola Is Now Curable by Medicalidiot on Tuesday August 13, 2019 @05:33PM (#20690501)
There's a significant amount of fake news around the Ebola outbreak epicenters, such as aid workers trying to take people's blood and other conspiracy theories. We have to keep in mind some of these places recently had a genocide and/or are generally unstable.
Re:Ebola Is Now Curable by gus_massa on Monday August 12, 2019 @10:16PM (#20682211)
> Ebola is a plant's virus adapted to trees.

I never heard that and I can't find that in Wikipedia. Do you have a link with more information about that?

Re:Ebola Is Now Curable by pvaldes on Tuesday August 13, 2019 @04:31AM (#20683799)
Is a plausible hypothesis. As we all know viruses do not fosilize easily, the origin of the virus is unknown (apart that is linked with tropical forest canopies in Africa). But there are several traits that would suggest a plant patogen that jump later to animals, maybe via plant sucking arthropods, and stablish later in bigger animals eating this arthropods. I could be wrong, I don't remember when I read it, but I remember that the idea triggered a click, and makes a lot of sense to me. I'm not expert in viruses evolution in any case so take this with a pinch of salt.

Ebolavirus is a genus comprising at least five species that can create similar outbreaks. I don't know if the treatment protects from all of them (Probably not). Is a fast mutating kind of creatures also. I guess that each future outbreak will need to rebuild an specifical treatment. The good news is that we know how to rebuild it fast, there is a new awareness of the problem, and african people are fixing some cultural traditions that helped to spread the virus in the past.

There are also other two genuses closely relative to Ebolavirus: Marburgvirus (produces a similar haemorrhagic fever in humans), and the spanish surprise Lloviu cuevavirus (poorly known but assumed harmless). Treatment designed for Ebola probably will not protect from Marburg disease, but I'm speculating.

Re:Ebola Is Now Curable by gus_massa on Tuesday August 13, 2019 @03:22PM (#20689297)
If you ever find a source for the virus for plant origin, I'd like to read it. (I'm not a biologist, but I'm curious. For example, I know about the relation with the Marburg disease.)