I think you need to find a recruiter to work closely with you. The good ones all do - ask around your former coworkers that you trust. Good recruiters will talk to you in-depth, hear what you are looking for, give resume advice, and pitch you to companies.

As a hiring manager, I would definitely be interested in your story and be looking for evidence of self-learning. What you have going against you is high salary expectations despite lack of domain expertise. So be ready to answer questions about how you have worked on various technologies over your career, had to learn them, successes you've had, etc.

Also, that job sounds horrible, you should get out for your mental well-being even if it requires a pay cut.