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Re:Brain Simulation Promised a Decade Ago Hasn't Succeeded by buboard on Thursday July 25, 2019 @08:30PM (#20531250)
the HH model is good enough to reproduce almost everything that is recorded from neurons (Thats why H & H got the Nobel prize after all). Even dendritic regenerative spikes are reproduced by such models. I think it's generally acceptable that one does not need to do molecular dynamics to recreate membrane voltages. LIF and AdEx are very crude approximations though (i.e. no dendritic spikes, no plateaus, impossible to use them to approximate compartmentalized calcium levels that induce plasticity). And if you go that route, you have to justify why they are a better choice than e.g. Izhikevich neurons or indeed just sigmoid units.
Re:Brain Simulation Promised a Decade Ago Hasn't Succeeded by marmaduke on Friday July 26, 2019 @09:26AM (#20534591)
> I think it's generally acceptable that one does not need to do molecular dynamics to recreate membrane voltages

everyone draws the line somewhere, this is yours. Even we take this statement to be true, you still have metabolic networks changing transmitter concentrations, dendritic arbors evolving in entirely unidentifiable ways, etc. The goal of modeling is not to say that every detail is there, but ones relevant to account for specific feature of data.

Re:Brain Simulation Promised a Decade Ago Hasn't Succeeded by buboard on Friday July 26, 2019 @09:59AM (#20534834)
While there is more detail that can be simualted, there is a vast very successful literature using compartmental models. Markram's work was the simulation of a cortical column with compartmental models anyway.