There are 20-some people running...I wouldn't call them a presidential candidate yet...more like presidential hopefuls.

And because big pharma seems to always win.

They are technically all candidates. The winner of the primary is a nominee.

Pharma gets what they pay for. Vote for someone who isn't beholden to them.

Yeah, but after continuing to vote for people that don't have backing and therefore never have a chance to start really is starting to feel like I am wasting my vote.

Hell, because of the Electoral College, my vote ultimately doesn't count if it isn't what the whole state picks.

they win because not enough people care!

Because the people that will likely win the nomination will almost certainly have big money, to include Big Pharma, behind them. Ads, research, propaganda, and aggressive ground games work, but they need money. Like multi-national corp or nation-state level money[1].

Hilary had some uncomfortable ties to Wall Street -- she was a Senator from NY, mind you -- and the DNC chair Debbie Wasserman-Schultz picked up a lot of Budweiser money by scrapping any DNC talk of Marijuana Legalization (DWS has long battle MJ Legalization in Florida, so she's been taking their money for a while, or was a sympathetic bribe for Alcohol). But I could have lived with that in exchange for working health care and sane foreign policy.

[1] see also: the russian firehose of propaganda -- https://www.rand.org/pubs/perspectives/PE198.html