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Re:“Evidence-based medicine has been hijacked”: John Ioannid... by DoreenMichele on Friday July 05, 2019 @12:32AM (#20359854)
Off the top of my head:

He does meta studies -- aka studies of studies -- and finds that most studies are flawed, so most of the evidence we think we have isn't really there.

It doesn't exactly make him popular because he calls into question a lot of existing supposedly "proven" medical science.

He talks a lot about the biased assumptions that are the foundation of a lot of the framing of studies. If your baseline framing is sufficiently flawed, the entire study is junk. He thinks a lot of studies are, in fact, junk.

Re:“Evidence-based medicine has been hijacked”: John Ioannid... by Nasrudith on Friday July 05, 2019 @01:51AM (#20360145)
Stupid question - what makes us think the meta studies are themselves valid?

Also wouldn't junk itself have many subclassifications as how it is junk? Say poor study data quality, wrong assumptions of wider applicability, wrong analysis or conclusions, etc.

Re:“Evidence-based medicine has been hijacked”: John Ioannid... by DoreenMichele on Friday July 05, 2019 @02:15AM (#20360233)
what makes us think the meta studies are themselves valid?

A. This is one guy, basically. I mean, I agree with him, generally, but not everyone does.

B. It's easier to poke holes in someone else's thing than create a good study.

So study A: "I wonder how fat you have to be to not fit through this door. Let's weigh people (instead of measuring them) to see how fat you have to be not fit through the door."

Study B: "It's a great question, but it's badly done. Weighing them won't work. Let's just interview people and write down their self reported height!"

Meta analyst: "Y'all are both wrong and stupid, geez."

Scientists A and B: "Let's take the meta-analyst out back and beat him up!" "Sounds good to me!"

Re:“Evidence-based medicine has been hijacked”: John Ioannid... by gilbetron on Friday July 05, 2019 @10:25AM (#20362725)
I'm sure the people doing the meta studies would be delighted to have other, independent people attempt to replicate their studies, but as they did it, and in other ways to verify their findings. Unlike many of the groups that did the studies this meta is studying, who often don't want any group do anything except confirm their findings because of the money and status behind their studies.
Re:“Evidence-based medicine has been hijacked”: John Ioannid... by icelancer on Friday July 05, 2019 @02:30AM (#20360305)
>> Stupid question - what makes us think the meta studies are themselves valid?

This is not a stupid question. Many meta studies are done by people with their own frameworks of deciding what is and isn't a legitimate approach to studying something. Unsurprisingly, their findings are overwhelmingly negative due to their own publication bias.

Meta studies are pretty worthless in my opinion. Primary studies in all fields should be forced to be published with open data, and any study that received - directly or indirectly - more than $1 from the public taxpayer should be forced to publish Open Access.

Lay bare all the raw data and let the software developers and data analysts get after it, not so-called expert meta reviewers.

Re:“Evidence-based medicine has been hijacked”: John Ioannid... by Jedd on Friday July 05, 2019 @03:14AM (#20360480)
> Lay bare all the raw data and let the software developers ...

Really can't tell if you're being sarcastic here, even in the context of HN.

> Meta studies are pretty worthless in my opinion. Primary studies in all fields should be forced to be published with open data ...

And until that happens meta studies are both worthwhile and one of the most effective ways to correlate and sensibly interpret the existing published data sets.