If an entire Sci-fi continuity were limited to just Sol and Alpha Centauri, this by itself would constitute an inexhaustible number of potential settings. In addition to planets, moons, asteroids, dwarf planets, Oort cloud and Kuiper belt class objects, there could also be space stations numbering in the tens of millions. Such a setting could use known physics, yet be incredibly vast. The Expanse is going in this direction, but doesn't go that far, and doesn't stick to known physics. (Though it remains closer to it than almost all Sci-fi continuities out there.)

"Saturn's Children" by Charles Stross is a good one (unfortunately he had to do away with humans to keep the space opera physically realistic).

Fortunately Amazon took it. If after three seasons of slow development it ended where we start to see answers, I would have considered it a scam. Not so insulting as Gallactica, but definitely annoying.