Mostly humans with radiation repair nanomachines and shielding could do just fine, I think. (Saying more would spoil Saturn's Children.) Humans commanding autonomous drones should figure more into Sci-fi. "Away teams" of drones in real life space fleets should be more prominent. Instead of a transporter shifting bodies, we could have the shifting of points of view through VR teleoperation. (Which is really what a transporter was for in the original Star Trek series: Changing locations with minimal production expense.)