Re:Ebola cases pass 2k as crisis escalates
by i_am_nomad on Wednesday June 05, 2019 @11:06AM
(#20105161)
To those of you worried about a global outbreak: USAMRIID is closing in on a highly effective (near 100%) treatment for Ebola. So far it is 100% successful in macaques, which is a good animal model for the disease in humans. The project lead spoke to my research group - his talk about Ebola, and some of the cultural and geographic challenges in fighting it, was fascinating.
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Re:Ebola cases pass 2k as crisis escalates
by jlmorton on Wednesday June 05, 2019 @02:01PM
(#20107299)
U.S. Army Medical Research Institute for Infectious Diseases is doing the important testing work, but the novel drug is GS-5734 / Remdesivir from Gilead Sciences.
https://www.gilead.com/purpose/advancing-global-health/ebola
Re:Ebola cases pass 2k as crisis escalates
by i_am_nomad on Wednesday June 05, 2019 @03:36PM
(#20108298)
Right, thank you for the clarification, I should have been specific about that.
Re:Ebola cases pass 2k as crisis escalates
by asdf21 on Wednesday June 05, 2019 @11:40AM
(#20105528)
Near 100% successful in preventing death specifically? Are there other health issues for survivors?
Re:Ebola cases pass 2k as crisis escalates
by TallGuyShort on Wednesday June 05, 2019 @02:26PM
(#20107598)
I'm curious to learn more about how well we can ramp up production and distribution of such drugs in the event of a fast-moving pandemic. With Ebola you have 1-2 weeks after symptoms before death is likely. You have a few more weeks after exposure, but you might not know you're exposed and I would assume the treatment needs time and can't save you at the last minute. If everyone around was clamoring for treatment, could you get your hands on it that fast?
Re:Ebola cases pass 2k as crisis escalates
by i_am_nomad on Wednesday June 05, 2019 @03:41PM
(#20108339)
Sorry, I don’t know much about large-scale production of that type of compound, it’s not my field. But, I would question the premise, in that Ebola is not a likely candidate for a fast-moving pandemic.
Re:Ebola cases pass 2k as crisis escalates
by TallGuyShort on Wednesday June 05, 2019 @04:29PM
(#20108787)
... well now I'm curious to what the likely candidates are :) This is one of those topics I could just sit and learn about all day, I think it's fascinating. If you or someone else in your research group were willing to do an AMA, I would thoroughly enjoy that.
Re:Ebola cases pass 2k as crisis escalates
by mieseratte on Wednesday June 05, 2019 @11:17AM
(#20105268)
Could you elaborate on those challenges?
Re:Ebola cases pass 2k as crisis escalates
by i_am_nomad on Wednesday June 05, 2019 @03:39PM
(#20108325)
For one thing, some of the burial practices and rituals in the region pose significant risks of communicating Ebola. And, when health workers recommend suspending those practices, those recommendations are not well-received.
Re:Ebola cases pass 2k as crisis escalates
by jbob2000 on Wednesday June 05, 2019 @12:42PM
(#20106253)
The doctors and medical staff are mostly white, while the people they are treating are mostly black. To the ignorant, this would appear like an attempt at a genocide or recolonization.
Re:Ebola cases pass 2k as crisis escalates
by mieseratte on Wednesday June 05, 2019 @07:44PM
(#20110205)
Is that actually the case on the ground, some type of "the doctors are actually the ones making us sick" scenario?
Re:Ebola cases pass 2k as crisis escalates
by HarryHirsch on Wednesday June 05, 2019 @07:58PM
(#20110282)
That's absolutely the case: https://www.nbcnews.com/news/world/congo-s-ebola-response-th...
Re:Ebola cases pass 2k as crisis escalates
by patagonia on Wednesday June 05, 2019 @11:25AM
(#20105354)
Is it effective for all current strains and future mutations of Ebola?
Re:Ebola cases pass 2k as crisis escalates
by maxerickson on Wednesday June 05, 2019 @11:34AM
(#20105448)
It appears to be effective against a range of viruses:
https://en.wikipedia.org/wiki/Remdesivir
But of course there's no guarantee, it's not really a great question when it comes to biology.
Re:Ebola cases pass 2k as crisis escalates
by phkahler on Wednesday June 05, 2019 @12:20PM
(#20105954)
There are vaccines being tested on people in DRC right now. Is there any data coming back on those? I dont care much about macaques.
Re:Ebola cases pass 2k as crisis escalates
by i_am_nomad on Wednesday June 05, 2019 @03:42PM
(#20108351)
As I mentioned, macaques are in this case a pretty good predictor for efficacy in humans. I don’t have data on the human trials though.