Working at a company who transitioned from startup to large company, the thing I see a lot of "just get shit done" startupy type people get killed on is that they can't just go do things themselves. They have to build consensus and get other teams to do the work for them. Once can see this as politics. One can also see this as leveraging large groups of employees to get work done.

The other big one I see is that at a certain point companies can afford to shift from "duct tape it till we get funding" to "we have funding, we can spend time engineering solutions." Which also means that they go slow, write way more docs, etc.