It is actually incredibly easy if you use a password manager and have your local pi-hole credentials all saved. Maybe 4 clicks and I've disabled both my pi-holes (primary and backup) for 15 minutes.

I've been running 2 pi-holes for almost a year. I've been surprised at how well they work and how few sites have issues. I've only encountered 2 problems: 1) Administering Google Ads... Of course it needs to be disabled. 2) Oddly enough Lowes website has very odd online ordering issues unless you disable the pi-holes.