macOS regularly forgets my pixel perfectly aligned monitor layout. I wrote displayplacer so that I could describe and apply monitor layouts (resolution/orientation/positioning) through the terminal. Now, upon plugging in, if my displays are all mixed up I hit a hotkey mapped through BetterTouchTool to apply a displayplacer profile.

Under the hood this is using Quartz Display Services to manipulate the displays. Let me know if this is useful and if there's any feedback.