They designed 20,000 specialized vector graphic icons. Do you think it's quick and/or cheap to do that?

It's not. But it's entirely orthogonal to this being an application vs. a Service as a Software Substitute.

This pricing is market-based though; if the market won't support it, the price won't exist. The parent's complaint is strange in that light: it's someone lamenting the loss of apparently vastly under-priced software, but framing it as unjust.

It may be so.Bu then again,JIRA is essentially an app that allows to drag a fancy digital post-it across 3 different stages..Yet somehow it is Atlassian booked 800M revenue last year...

JIRA is much more complex than that; unlike with BioRender, yours is an unfair simplification. Your argument can be rescued though by replacing JIRA with Trello.

Which makes it less, not more, useful. Zombie states, too many workflow possibilities tending to the baroque.