Well, human children do train their vision in a lot of different ways while playing, and probably very early develop a mechanism for dealing with all kinds rotated objects.

For some objects though, even adults are not instantly good, reading text upside down is something that is initially very hard, but with some practice it can be done, I've met some teachers that can do it from years of tutoring people from other sides of desks.

The way something looks can definitely change based on its rotation -- see http://thatchereffect.com for example.