Re:Cambridge scientists create living organism with redesign...
by 781 on Wednesday May 15, 2019 @06:55PM
(#19924596)
Not an expert, but for example maybe decoding the TCG instruction (in the ribosome) is slower or uses more energy.
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Re:Cambridge scientists create living organism with redesign...
by Amygaz on Wednesday May 15, 2019 @07:38PM
(#19924824)
I doubt that's the only reason but according to this table [0], AGC triplets are 2x more prevalent than UGC in that bacteria.
Edit: this the frequency of that codon being used o the genome sequence. But the assumption could be that it is also preferably produced as a t-RNA so it can replicate its genome efficiently.
It's more likely that they have introduced errors, or non-preferred patterns, which affect the number of replication forks and stall the replication machinery.
[0] https://www.kazusa.or.jp/codon/cgi-bin/showcodon.cgi?species...