That statement from Rich Hickey makes no sense at all, because we aren't born knowing how to play instruments. And if your brand new instrument is weird, then not many people are going to bother learning how to play it.

Thinking that "ease of use" should not be considered because [favourite reasons] is probably the number one misunderstanding software engineers have about humans. :) Please read Norman's "The design of everyday things", before accidentally making the life of someone miserable through software.