Dart had gradual types but didn't enforce them at runtime because of performance. The PyPy devs don't believe that type annotations help them for performance (http://doc.pypy.org/en/latest/faq.html#would-type-annotation...). Also there is no JS engine that uses TypeScript annotations so far to improve performance.

Types are usually on the wrong boundary: e.g. Integer doesn't state whether that value fits into a register or is a Bignum.

Also: Aren't some type checks quite expensive? So more expensive than a simple map/class/shape check? E.g. passing an array from untyped code to a signature with something like `Array<Integer>`. Wouldn't a runtime that verifies signatures have to check all elements in the array to be actual Integers?