He also points out that, ever since Newton, the dream of mechanistic world was shattered, and with it, any hope that science would help us "make sense of the world" in a truly satisfying sense. Instead, we have become content with modelling the world mathematically and predicting how it will evolve.
Of course, space-time and quantum mechanics have driven additional nails in the coffin of a truly understandable world.
I'd think the opposite. The fact the world can work at least as strangely as relativity and quantum mechanics suggest, and we still figured those out as much as we have so far, reassures me in our ability to figure out the world we exist in.
However, we can still hope to model and predict it more accurately than we would have ever hoped before, so there is that :)
It may be (probably is) that "what is this" or "why does it do that" are just meaningless questions, in the sense a child (or adult who hasn't re-calibrated their expectations of what science can tell them) means them. Which is interesting itself, I suppose, but at that point just go study philosophy and art, if that's why you were into science in the first place—and I think it's why everyone at least begins to be interested in science.
[EDIT] in particular it's frightening how fast kids' questions stymie an adult because the adult realizes that they're only a step or two away from "why is there something instead of nothing, and also what is something?" and... good lord, at that point seriously just go become religious or get really into philosophy or something, because you're outta luck, kid, sorry, we don't have any actual answers, just observations about what all this stuff does, but no we can't tell you what "stuff" or "does" are.