If I have to do any DOM manipulation outside of perhaps hiding or showing an element based on a button press, I typically find it far more unwieldy to do all that stuff with jQuery than just scaffolding out a quick Vue component.
Plus, there is a build available with a runtime template compiler, so you can just pull that in via a CDN and prototype without needing a build step.
Obviously, it varies a lot based on the sort of things you build, but I’ve found it to have sped up my prototyping process enormously.
I didn’t (and still don’t) know any of the $cool_kids front end frameworks. But it couldn’t have been a SPA anyway. Each of the pages were created by a CMS that ran on the web and in a native mobile app that had to be able to work offline.
I like Vue, never really jumped into react, but I hate using npm and all of the javascript build tools.. I end up fighting with them for a while and decide it's back to jQuery and simplicity. Always works.
I think I'll always be prototyping in Jquery.
Large stuff we built in React, Redux etc... But if you need a quick tool or prototype, just adding a single <script> tag to get JQuery from a CDN and you're ready to go. Nothing is going to beat that, right?