Yes. I've tried implementing some of these on my wife's laptop after using them myself for some time and not having any problems. Then quickly learned that the sites she comes across while browsing are far far more likely to break with these tools than the sites that I (a computer geek) visit.

I've had to dial it back significantly. Disconnect is the only blocker that has passed the wife test. I originally discounted it because the UI for dealing with breakage is worse than Privacy Badger or Ghostery (The default UI doesn't list blocked conent, the graph is harder to see host names at a glance, and the button to temporarily disable all blocking is not as obvious). But the fact that it is more conservative in what it blocks to begin with makes up for it. I still wouldn't enable it for people I don't live with though.

I was also shocked at how frequently HTTPS Everywhere breaks things. I stopped using that myself (and I use uMatrix, with stricter than default base rules).

I'm testing out Decentraleyes right now. It claims to be 100% non-breaking, and so far that appears to be the case. The problem it is addressing (tracking browsing habits via JS libraries) isn't one of the biggest privacy concerns out there, but if it doesn't break anything, and decreases bandwidth to boot, why not!