I have a friend who experienced 5-MeO-DMT in this fashion three times. In each case he reported that it was a powerfully overwhelming ecstatic experience; it felt like contact with the divine. A key feature of the experience was that his ability to control the trip was completely overwhelmed; it is an experience of surrender. His depression improved because he gained a temporary perspective on the world which was utterly suffused with love and light; after it faded, he still remembered what it had felt like, and knowing that it was possible to see the same world in such different ways based on nothing but a chemical state change in the brain has made it possible for him to stop taking his own current state of mind so seriously. It is just one of many possible ways of experiencing the world, after all.