Please: plague epidemics were massive outbreaks that lasted a somewhat short amount of time. No diseases of this kind had ever been prevented by vaccination (you just don't have time to develop/distribute a vaccine, think Ebola last time).

Vaccines aren't made for epidemics: they are for _endemic_ diseases, and especially the ones which target children. Vaccines are good for things like polio, smallpox and Measles. But plague, Cholera, SARS, etc. are delt with emergency measures: quarantine, not vaccines.

The problem (and there is indeed a problem) with antivaxs, is child mortality, not «plague-like epidemics».