Re:One More Time, with Big Data: Measles Vaccine Doesn’t Cau...
by z92x38y12 on Tuesday March 05, 2019 @04:51PM
(#19314589)
lot of little secrets.
- Industry trial funding and other conflicts of interest
- No real placebo test - and it is normal according to the expert.
- etc.
"No included trial in the Cochrane review used a placebo comparator
All 26 trials included in the Cochrane review used active comparators: adjuvants (aluminium hydroxide (Al[OH]3) or amorphous aluminium hydroxyphosphate sulfate [AAHS]) or hepatitis vaccines."
"The Cochrane authors mistakenly used the term
placebo to describe the active comparators. They
acknowledged that ‘The comparison of the risks
of adverse events was compromised by the use of
different products (adjuvants and hepatitis vaccines)
administered to participants in the control group’.
Nevertheless, this statement can easily be overlooked, as it comes after 7500 words about other
issues in the discussion and under the heading
‘Potential biases in the review process’. Active
comparators was not a bias in the review process
but a bias in the design of the HPV vaccine trials."
source:
"The Cochrane HPV vaccine review was incomplete and
ignored important evidence of bias"
BMJ Evidence-Based Medicine October 2018 | volume 23 | number 5 |
- Industry trial funding and other conflicts of interest
- No real placebo test - and it is normal according to the expert.
- etc.
"No included trial in the Cochrane review used a placebo comparator All 26 trials included in the Cochrane review used active comparators: adjuvants (aluminium hydroxide (Al[OH]3) or amorphous aluminium hydroxyphosphate sulfate [AAHS]) or hepatitis vaccines."
"The Cochrane authors mistakenly used the term placebo to describe the active comparators. They acknowledged that ‘The comparison of the risks of adverse events was compromised by the use of different products (adjuvants and hepatitis vaccines) administered to participants in the control group’. Nevertheless, this statement can easily be overlooked, as it comes after 7500 words about other issues in the discussion and under the heading ‘Potential biases in the review process’. Active comparators was not a bias in the review process but a bias in the design of the HPV vaccine trials."
source:
"The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias"
BMJ Evidence-Based Medicine October 2018 | volume 23 | number 5 |
https://ebm.bmj.com/content/ebmed/23/5/165.full.pdf