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A comment on Why Drugs That Work in Mice Don't Work in Humans.

Re:Why Drugs That Work in Mice Don't Work in Humans by Amygaz on Thursday February 28, 2019 @07:45AM (#19270946)
Any mice trial should use 4 different breeds: one of the academic hallmark (black6 or balb/c) for publication purpose, one that represent your model (or so you think) because that’s the logical thing to do, and a truly wild type one (captured in the wild) to capture the noise.

Even this bias longevity piece needs to do that. This 4 breeds will all have different immune system, cognitive behavior and lifestyles, which are all central to aging.

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Re:Why Drugs That Work in Mice Don't Work in Humans by klmr on Thursday February 28, 2019 @09:49AM (#19271617)
The issue with that approach is that you’d multiply the number of sacrificed animals by 3 (or 4, did you forget a breed?), for limited gains in insight. Your approach would be a lot more defensible if it didn’t involve killing vastly more animals, and a fairly large increase in research cost. These things are always a balance, and there’s no evidence that always using your approach would be worth it.
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Re:Why Drugs That Work in Mice Don't Work in Humans by ennisthemennis on Thursday February 28, 2019 @12:41PM (#19273222)
I agree "any mice trial" is too strong a statement, and also 4 groups is kind of infeasible. But I do think there is not enough research on how these particular inbred mouse strains might bias research. Even the same strain sourced from different companies have produced different results, due to microbiome differences [1]. It's possible that we are way "overfitting" to these particular academic mice

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870873/

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Re:Why Drugs That Work in Mice Don't Work in Humans by woliveirajr on Thursday February 28, 2019 @08:28AM (#19271169)
That makes 3...
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Re:Why Drugs That Work in Mice Don't Work in Humans by magicalhippo on Thursday February 28, 2019 @11:13AM (#19272371)
The 4th is a group of dead mice, to make sure you don't accidentally start a zombie apocalypse.
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Re:Why Drugs That Work in Mice Don't Work in Humans by SubiculumCode on Thursday February 28, 2019 @01:01PM (#19273413)
Jokes are discouraged on HN, but you did make me snort out loud.
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