I didn't know they had smart munitions, interesting. I guess what I'm picturing is a Mk-47 with smart munitions mounted on a remote weapons station on an APC/IFV. Putting it on an armored vehicle makes it more maneuverable of course, but it also provides protection to the gunner. Unlike warfare in a more open setting, due to the presence of buildings you may have to get well within the range of small arms fire to have line of sight to your target.

And apparently there's some work being done on equipping Stryker's with the XM813, a 30mm Bushmaster autocannon that can fire programmable air bursting rounds. Which might accomplish the same thing.

In the article, the Strykers proved to be too vulnerable in the urban environment. They brought in Bradleys and M1 Abrams tanks instead.

Very true. Well, the Bushmaster prototype could probably be put on the Bradley in place of the Bushmaster that's already there. As for smart grenades, I don't think there's an obvious place to put one on a Bradley, but some versions of the Abrams TUSK included a CROWS remote weapons system with an HMG, maybe you could replace the HMG with the grenade launcher?

There's definitely a need for armored vehicles better suited to urban combat. Maybe the Army's Armored Multi-Purpose Vehicle program will provide something. I don't know much about how vehicle armor works, but maybe there's room for optimization? I mean, it's not like the enemy here is firing APFSDS rounds, or using advanced ATGMs. It's all IEDs and RPGs at close range. I know there's stuff like having a V-shaped hull improves performance against mines, and slat and cage armor to deal with explosively formed penetrator type weapons, but I wonder if there's other techniques that can produce a survivable vehicle without needing a full, 60+ ton tank

Yup. EFPs are no joke.