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A comment on Compass Pathways has set itself up to be the first legal provider of psilocybin. Parent comment

Re:Compass Pathways has set itself up to be the first legal ... by bdamm on Friday January 04, 2019 @01:49PM (#18826564)
Unclear. I have close family that is having marked and unprecedented success in treating serious depression by microdosing psilocybin below the psychedelic threshold. The result is profound, sustained, and after trying a dozen different approved psychiatrist prescribed drugs to find help can not be a placebo effect as surely any of those would have been just as effective.
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Re:Compass Pathways has set itself up to be the first legal ... by ada1981 on Friday January 04, 2019 @02:19PM (#18826853)
Out of curiosity, have they tried macro-dosing to be ineffective?

Ie instead of ongoing microdosing, having a 2-3g experience once or twice.

I have very little faith in main stream psychiatric care to provide anything other than blunt palliative options (often with lethal conseuences).

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Re:Compass Pathways has set itself up to be the first legal ... by bdamm on Friday January 04, 2019 @03:03PM (#18827167)
They have not yet, because we haven't found a way to provide a safe environment for this person to be in that can be sustained long enough to cover the entire experience. Providing safety would include alleviating their responsibilities, which includes child care, so that gets pretty complex.
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Re:Compass Pathways has set itself up to be the first legal ... by ada1981 on Friday January 04, 2019 @04:33PM (#18827837)
Understood. Wishing you an afternoon and the support needed soon.

Also really glad you have found relief with microdosing!

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Re:Compass Pathways has set itself up to be the first legal ... by kristofferR on Friday January 04, 2019 @05:03PM (#18828107)
There isn't a clear threshold in regards to microdosing. You're still getting the psychedelic effect from the psilocybin, just proportionally less.
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Re:Compass Pathways has set itself up to be the first legal ... by Dylan16807 on Friday January 04, 2019 @10:49PM (#18829786)
If your state of consciousness is altered by 2% that's just called a normal day.

There is a very qualitative difference between tripping and not-tripping. (With a blurry line but you can easily stay on one side of a blurry line.)

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Re:Compass Pathways has set itself up to be the first legal ... by sierdolij on Friday January 04, 2019 @06:47PM (#18828864)
It's uncertain if microdosing a particular ligand has any scientifically-proven evidence of efficacy without studying it. In many instances, it maybe a shared delusion placebo effect and/or socially-reinforced fad.
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