You can still give them aspirin and/or ibuprofen. People have done it for over half a century, and the sky hasn't fallen.

How much/often were those people taking ibuprofen to have those effects? And how worse were they than the baseline? From what I see, they took 3 times a day for 2-3 weeks (not just to pass a small fever), and they were older men to begin with (e.g. already on a downfall for testosterone).