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Re:Ibuprofen alters human testicular physiology to produce c... by lelandgaunt on Saturday December 29, 2018 @11:29PM (#18787388)
Long term acetaminophen usage is linked to a reduction in empathy.[0]

[0]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015806/

Re:Ibuprofen alters human testicular physiology to produce c... by sawhit on Saturday December 29, 2018 @11:41PM (#18787430)
As far as I can tell, the article linked says that there was a reduction in empathy (for pain) directly after being administered acetaminophen. I'm not seeing anything about long term use.