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Re:Prions, Nearly Indestructible and Universally Lethal, See... by nonbel on Monday December 10, 2018 @03:07PM (#18650801)
You just use bleach and then autoclave:

>"combining autoclaving (even at 121 degrees C) with a sodium hydroxide treatment is extremely effective." https://www.ncbi.nlm.nih.gov/pubmed/10658760

Re:Prions, Nearly Indestructible and Universally Lethal, See... by coryrc on Tuesday December 11, 2018 @02:16AM (#18653684)
Bleach is sodium hypochlorite; sodium hydroxide is lye/caustic soda.
Re:Prions, Nearly Indestructible and Universally Lethal, See... by nonbel on Tuesday December 11, 2018 @09:40AM (#18655533)
Yea, sorry. Earlier in the abstract it mentioned sodium hypochlorite then I didnt read closely: "Strong sodium hypochiorite solutions achieve inactivation but other chlorine-releasing compounds are less effective"

Usually there is some sodium hydroxide in standard sodium hypochlorite bleach solution as well though, perhaps that explains why they reported it is the most effective of the chlorine bleaches.