If you include a couple of C++ stdlib headers you're already well past 45kloc per compilation unit (for instance, including <vector> pulls in about 25kloc of code). Such a file usually compiles in a second or so, but the problem in C++ projects is that each source file pulls in the same headers over and over, which explodes the line count the compiler has to crunch through (I bet that in most bigger C++ projects, the actual project code is less than 5% of what the compiler actually needs to compile).
C is much more predictable, a 45kloc C project should compile and link in under a second for a full rebuild without optimizations, and at most 2..3 seconds with optimizations. The link-step is usually the critical part, since that's hard to speed up by throwing more hardware resources at it.
I have Rust projects that are many times smaller but take much more time for a non-incremental build. Of course, a large difference is that a fresh Rust build (after a cargo clean) compiles all its dependent crates, whereas many C/C++ libraries are provided pre-compiled by whatever system you are compiling on.
Couple of seconds for 45k lines - I think you are too demanding :) But if C++ can compile it in couple of seconds - great, good competition for Rust :)
I don't think 45k LoC could be considered big, and I _do_ think a couple minutes compile time is a problem. I say that as a C++ programmer, a full recompile will easily get me out of the zone